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KMID : 1013220060040020128
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Jouranl of the Korean Society of Clinical Toxicology
2006 Volume.4 No. 2 p.128 ~ p.130
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A Sensorimotor Polyneuropathy Caused by Chronic Phenytoin Therapy
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Han Dong-Chul
Park Hyeon-Mi
Shin Dong-Jin
Lee Yeong-Bae
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Abstract
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Phenytoin has been used globally as an effective anticonvulsant. Among its adverse effects, peripheral neuropathy including polyneuropathy has sometimes been reported. We report a case of sensorimotor polyneuropathy associated with high serum level and long-term phenytoin therapy. A 29-year-old male presented with motor weakness in all extremities. He was treated with phenytoin (400 mg/day) for about eight years because of generalized tonic clonic seizure. During none conduction assessment, sensorimotor polyneuropathy was discovered.
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KEYWORD
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Seizure, Phenytoin, Polyneuropathy
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